Korean scientists have successfully identified a cell-specific molecular network in autism spectrum disorder. It is expected to lay the foundation for the treatment of autism spectrum disorders.It was published in the magazine molecular psychiatryThe research was conducted by a team of researchers led by Professor Min-shik Kim of the Department of New Biology at DGIST (Daegu Gyeongbuk Institute of Science and Technology).
Autism Spectrum Disorder is a developmental disorder known to begin in early childhood. It is a neurodevelopmental disorder characterized by persistent deficits in social communication and interaction-related behaviors, with a restricted range of behavioral patterns, interests, and activities, and restricted repetitive behaviors.
Most people with Autism Spectrum Disorder have behavioral disorders and may have other developmental disorders. Early diagnosis of autism spectrum disorders is made much later, as there is currently no precise molecular diagnostic method. Although behavioral management therapy has had some success in improving symptoms, there is no effective treatment at the molecular level.
To extract prefrontal cortex tissue, Prof. Min-sik’s team utilized the Cntnap2-deficient model, a spectrally impaired mouse model established by Prof. Lee Yong-Seok’s team at the Seoul National University School of Medicine, using mass spectrometric analysis. We performed an integrated quantitative proteomics and metabolomics analysis based on In addition, by comparing and analyzing big data of autism spectrum disorder patients reported so far, we confirmed that problems occurred in networks such as excitatory neuron metabolism and synapses.
Professor Min-shik Kim of the Department of Neobiology said, “The multi-omics integrated analysis technology developed in this research will advance the pathological understanding of autism spectrum disorders, and will lead to the discovery of integrated networks from cell differentiation at the molecular level. made it possible,” he said. It is induced by specific autism genes into biological information,” he added, adding, “By integratively analyzing various models, we are trying to discover the core network of autism spectrum disorders and discover therapeutic targets. ‘ added.
Reference: “Integrated multi-omics analysis of Cntnap2-dependent molecular networks in autism spectrum disorder” by Wooyoung Eric Jang, Ji Hwan Park, Gaeun Park, Geul Bang, Chan Hyun Na, Jin Young Kim, Kwang-Yol Kim, Kwang Pyo Kim, Chan Young Shin, Joon-Yong An, Yong-Seok Lee, Min-Sik Kim, 17 October 2022, molecular psychiatry.
This research was supported by the Brain Science Fundamental Technology Development Project of the Ministry of Science, Technology and Information Communication.