Illustrated by Lauren Boglio
This week we kick things off with a PsyArXiv preprint on how to improve measurement accuracy and increase reproducibility in neuroscience.
Key Statement: The only answer to the replication crisis is not just giant samples. Additionally, the measurements should be more accurate. This primer will show you how to do this. #MRI, #EEG, #meg, #EMG, #electro-cardiogram, #EDA, # Eye tracking, #endocrinologyWhen #Genetics.
— Mario Reuters (@reutter_mario) January 19, 2023
“Huge samples are not the only answer to the problem. replication crisisMario Reuter, a professor of psychology at the University of Würzburg in Germany, who was one of the 25 researchers involved in the project, tweeted: “Furthermore, we need to make our measurements more accurate.”
Various factors can affect measurement accuracy in nine ways, including MRI, EEG, and eye-tracking, the team reports. For example, infrared eye trackers measure brown eyes more accurately than blue eyes.
“I was happy to be involved in this work. Multi-researcher project!Louisa Kulke, Professor of Neurocognitive Developmental Psychology at Friedrich-Alexander University in Erlangen, Germany, tweeted:
How can we improve the accuracy of EEG research – it was an honor to be part of this multi-researcher project! https://t.co/ovFPeqPUqa
— Louisa Kulke (@Lou_Kulke) January 19, 2023
Elsewhere on Twitter, neuroscientists Science Translational Medicine “Using epigenome editing tools… Rescuing Rett Syndrome Neurons,” tweeted research leader Sean Liu, an assistant professor of physiology and cellular biophysics at Columbia University.
We are pleased to share our recent paper on the application of epigenome editing tools to tackle neurodevelopmental diseases. Here are some points we learned.
Multiple epigenome editing of MECP2 to rescue neurons in Rett syndrome https://t.co/HZB9hc4OVf
— Shawn Liu (@ShawnLiu_Lab) January 19, 2023
This study “serves as an example Addressing other X-linked human diseasescontinued Liu.
5/5 Such a multiple epigenome editing approach more effectively rescued electrophysiological defects in edited Rhett neurons. We hope that our study will serve as an example for tackling other X-related human diseases. pic.twitter.com/Vp1Eo0yIM9
— Shawn Liu (@ShawnLiu_Lab) January 19, 2023
“As Field sees, we expect more to come out of this application. Breakthroughs beyond rare symptomstweeted Twitter user BowTiedBiotech.
???? ???? Epigenetic editing – nice work!
???? Expect more to come out of this application as this field looks to breakthrough beyond rare signs https://t.co/TVsxmbcQmD
— BowTiedBiotech ???????????? | | Biweekly Biotech Substack (@BowTiedBiotech) January 20, 2023
One user asked when this strategy could be tested in Rett patients. Liu said the team is “working hard to test it in vivo using an animal model, and hopefully, start a clinical trial“
We are working hard to test this strategy in vivo using animal models and hopefully initiate clinical studies.
— Shawn Liu (@ShawnLiu_Lab) January 21, 2023
Scientists then considered some new biological insights about autism from research published in . sergenomics This month is”Human brain-specific interactome Greta Pintacuda, a research scientist and researcher at the Lage Lab at the Massachusetts Institute of Technology (MIT) in Cambridge, tweeted.
Very proud to share today’s workout @Sergenomicshere we use the human brain-specific interactome as a framework to complement genetic and transcriptomic data leading to biological insights into ASD. @kasper_lage @yuhanhsu @Stanley Center @HSCRB https://t.co/cBcglh0ihM
— Greta Pintacuda (@gretapinta) January 24, 2023
“Protein-protein interactions of 13 autism genes in human Ngn2 neurons nice convergence and some surprises! Michele Gabriele, her research fellow in Anders Sejr Hansen’s lab at MIT, tweeted.
Protein-protein interactions of 13 autism genes in human Ngn2 neurons showed great convergence and some surprises! https://t.co/CGrWxXyDxm
— Michele Gabriele ???????????? (@labronic_mike) January 25, 2023
This next thread leads to the question, “How does the brain perceive social contact as pleasant?”
https://t.co/g7OuAqjgwb
— Dr. Leah Elias (@leahthePhDya) January 23, 2023
“Our story skin to brain Leah Elias, a postdoctoral fellow in the Seth Blackshaw lab at Johns Hopkins University in Baltimore, Maryland, tweeted in a thread detailing her findings. cell this month. Elias and her colleagues found that neurons in the Mrgprb4 lineage are involved in rewarding social contact behavior. Researchers say this fills an important knowledge gap.
spectrum In May 2019, Deep Dive covered how social contact shapes autism traits.
Katerina Fotopolou, professor of psychodynamic neuroscience at the University of London, UK, wondered:touch addiction‘ could be the next step in research.
Neuroscience of skin pleasure! ‘Emotional contact’ neurons determine sexual behavior, the felt value of sexual interaction, and the brain’s response to relevant regions in mice. Will the next stop touch the addiction? https://t.co/btHUVcgffN
— Cut Lab (@Katlab_UCL) January 23, 2023
“super cool story Pleasant touch And a beautifully written Twitter thread to help explain it all!” tweeted Kate Sadler, professor of neuroscience at the University of Texas at Dallas.
A super cool story about haptics and a beautifully written Twitter thread that helps explain it all! Congratulations to everyone involved! https://t.co/kxaN75kHkg
— Kate Sadler (@KateSadlerPhD) January 23, 2023
That’s it for this week’s community newsletter. If you have any interesting social his post suggestions that you have seen in the autism research field, feel free to email me. [email protected].
Please follow us Facebook, twitter (@spectrum), Instagram When LinkedIn.
apply to get the best spectrum Directly to your inbox.
Citing this article: https://doi.org/10.53053/ZMIX1514
