Living in the southeastern US ‘stroke belt’ may be a risk factor for CKD

Among other risk factors, researchers identified living in the southeastern “stroke belt” of the United States as an independent risk factor for chronic kidney disease. American Journal of Kidney Disease.

Furthermore, albuminuria showed a higher association with CKD in blacks compared to whites.

“Previous studies have investigated risk factors for the development of CKD and/or longitudinal eGFR decline in a large US population-based cohort.” Catherine L. Chan, MD, PhD, A nephrologist and colleague at the University of Vermont wrote. “However, few studies are substantially representative of blacks, none are geographically diverse, and the extent to which standard CKD risk factors differ by race and racial/ethnic Traditional CKD risk factors that limit our ability to examine the extent to which differences in CKD may be explained, or the extent to which the risk of developing CKD varies by region.”

In an observational cohort study, researchers surveyed 4,198 black and 7,799 white participants aged 45 and over who were recruited between 2003 and 2007, and divided them by race, gender, or region in the United States. We determined whether the risk factors differed. /min/1.73m².

The researchers followed the patients and measured eGFR again approximately nine years after enrollment. Considering changes in eGFR as the primary outcome of the study, the researchers assessed age, gender, race, region, education, income, systolic blood pressure, BMI, diabetes, coronary heart disease, hyperlipidemia, smoking, albumin Urine was evaluated as the exposure.

Using linear regression and modified Poisson regression, researchers identified relationships between risk factors and key outcomes stratified by race, gender, and region.

Overall, 9% of participants developed CKD. Analysis reveals Alabama, Arkansas,

Georgia, Louisiana, Mississippi, North Carolina, South Carolina, and Tennessee independently correlated with changes in eGFR and development of CKD. In addition, black patients were more likely than white patients to have albuminuria associated with changes in her eGFR.

Researchers suggest that living in the southeastern stroke belt may expose patients to a variety of environmental conditions, including heat, air pollution, and water quality.

“In summary, in this large cohort study of black and white adults, traditional risk factors for CKD demonstrate an increased risk of CKD and eGFR decline in blacks compared to white adults. describes and supports an emphasis on addressing modifiable risk factors such as diabetes, hypertension and obesity, and reducing CKD imbalances. were stronger risk factors for CKD and eGFR decline in black participants and residents of the stroke zone compared with those living outside the stroke zone and those living outside the stroke zone,” wrote Cheung et al. “Additionally, living in the US stroke belt is an independent risk factor for developing CKD, an observation that requires further research to determine the key factors underlying this finding.”