Infants born to mothers who had diabetes during pregnancy are at increased risk of experiencing a range of developmental disorders, including ADHD, autism and cerebral palsy, according to new research results.
Exposure to type 1 diabetes, type 2 diabetes and gestational diabetes poses different risks for babies born to mothers who suffered from these conditions during pregnancy, according to findings published last week in a medical journal. Developmental Medicine and Pediatric Neurology.
Researchers at National Cheng Kung University Hospital in Taiwan conducted a retrospective cohort study of 877,000 infants born between 2004 and 2008 in Taiwan. They focused on maternal diabetes during pregnancy and a wide range of neurodevelopmental disorders, including autism spectrum disorder (ASD), attention deficit/hyperactivity disorder (ADHD), developmental delay, intellectual disability, and stroke. , analyzed health insurance claims data for that period. Paralysis, and epilepsy/infantile spasms.
Overall, 388 children, approximately 0.04%, were exposed to type 1 diabetes in utero. More than 8,700 infants, or about 1% of infants, were exposed to her type 2 diabetes, and more than 90,000 infants were exposed to gestational diabetes.
Infants exposed to type 1 diabetes were at increased risk of suffering from neurodevelopmental disorders.Type 2 diabetes and gestational diabetes also increased the risk of neurodevelopmental disorders, but not as much as type 1 diabetes.
Exposure to type 1 diabetes was associated with an increased risk of developmental delay, intellectual disability, and epilepsy/intellectual spasms in children born to women who suffered from this condition during pregnancy.
Type 2 diabetes increased the risk of autism, ADHD, developmental delay, intellectual disability, cerebral palsy, and epilepsy/intellectual spasms in children born to women who had the condition during pregnancy.
Having gestational diabetes during pregnancy increases the risk of autism, ADHD, and developmental delay.
“Mechanistic studies are needed to investigate how maternal conditions such as diabetes shape brain development in utero,” said author Pao-Lin Kuo, M.D., Ph.D., of National Cheng Kung University Hospital. said.
diabetes risk during pregnancy
All forms of maternal diabetes lead to an increased state of chronic inflammation. Researchers have determined that inflammation can have a wide range of side effects on the body, including effects on the uterus, placenta, and fetus, such as the delivery of oxygen and nutrients to the fetus.